Pharmacological management of neurobehavioral disorders following traumatic brain injury—A state-of-the-art review

Abstract—Pharmacological management of neurobehavioral disorders following traumatic brain injury (TBI) is common
practice. However, the evidence available to guide this practice remains sparse. This review summarizes, in brief, the state of knowledge, organized via a time continuum from injury as well as by symptom complex. The areas of neuroprotection,
hypoarousal, attention and memory deficits, aggression, agitation, depression, and mania are reviewed. The literature wassearched with PubMed on the terms “traumatic brain injury” or “brain injury” with “pharmacology” (and the symptoms according
to which this review is arranged). Additional searches were conducted with the specific symptoms as search terms, crossed with the therapeutic agents or drug classes discussed. Where a paucity of prospective data exists, case reports and retrospective studies are included. Studies to date have yielded minimal positive
evidence for enhancing function, memory, and behavior after TBI. No single agent likely will become sentinel in the recovery process, and combination therapy in the acute and postacute settings are required. A need exists to further define the
role of psychopharmacology in postacute TBI medicine and the specific characteristics of subpopulations who might benefit.

Comments: Click on title for PDF. DM